139101-58-9 Usage
Uses
Used in Pharmaceutical Industry:
2(3H)-Benzoxazolone, 5-chloro-6-(2-chlorobenzoyl)-3-[2-(4-pyridinyl)ethyl]is used as a potential pharmaceutical agent for its antitumor, anti-inflammatory, and analgesic properties. The presence of the chloro and pyridinyl groups may enhance its reactivity and biological activity, making it a valuable target for further research and development in the pharmaceutical field.
Used in Drug Discovery and Development:
In the drug discovery and development process, 2(3H)-Benzoxazolone, 5-chloro-6-(2-chlorobenzoyl)-3-[2-(4-pyridinyl)ethyl]is used as a lead compound for the design and synthesis of new drugs. Its unique structure and potential biological activity make it an interesting target for the development of novel therapeutic agents.
Used in Medicinal Chemistry Research:
2(3H)-Benzoxazolone, 5-chloro-6-(2-chlorobenzoyl)-3-[2-(4-pyridinyl)ethyl]is used as a subject of study in medicinal chemistry research to understand its structure-activity relationships and optimize its pharmacological properties. This research can lead to the discovery of new drugs with improved efficacy and safety profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 139101-58-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,1,0 and 1 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 139101-58:
(8*1)+(7*3)+(6*9)+(5*1)+(4*0)+(3*1)+(2*5)+(1*8)=109
109 % 10 = 9
So 139101-58-9 is a valid CAS Registry Number.
139101-58-9Relevant academic research and scientific papers
Synthesis of 3-(2-pyridylethyl)benzoxazolinone derivatives: Potent analgesic and antiinflammatory compounds inhibiting prostaglandin E2
Safak,Erdogan,Palaska,Sunal,Duru
, p. 1296 - 1299 (2007/10/02)
Fourteen new 3-[2-(2- and/or 4-pyridyl)ethyl]benzoxazolinone derivatives have been synthesized by reacting 2- and/or 4-vinylpyridine and appropriate benzoxazolinones. Their chemical structures have been proven by IR, 1H-NMR, and elemental analysis. Analgesic activities of these compounds were investigated by a 'Modified Koster's Test'. Except for compounds 10 and 11, all the new derivatives showed higher analgesic activities than aspirin. Therefore the compounds were screened for their antiinflammatory activities using the carrageenan hind paw edema test. The compounds (6, 7, 8, 9, 14, and 17) that showed high antiinflammatory activity were then further screened for their ability to inhibit prostaglandin E2 (PGE2) induced paw edema. Although all the benzoxazolinone derivatives synthesized in this study showed higher antiinflammatory activity compared to indomethacin, those without a substituent at the 6-position of the ring were significantly more active than the rest of the group, and their ulcerogenic activities and ED50 values indicate them as promising derivatives for further study.
