1391014-03-1Relevant articles and documents
Synthesis, characterization and evaluation of antimicrobial activity of some novel 1,2,4-triazoles and 1,3,4-thiadiazoles bearing imidazole nuclues
Aouad, Mohamed Reda,Rezki, Nadjet,Kasmi, Mohamed,Aouad, Linda,Rezki, Merieme A.
experimental part, p. 1141 - 1154 (2012/09/07)
A series of N1-[(4,5-di and 1,4,5-triphenylimidazol-2-yl) thioacetyl]- N4-alkyl/aryl-thiosemicarbazides 3-7 were synthesized from (4,5-di and 3,4,5- triphenylimidazol-2-yl)thioacetic acid hydrazide 1, 2. The treatment of compounds 3-7 with NaOH gave 5-[(4,5-di and 1,4,5-triphenylimidazol-2-yl)-3- thiomethyl]-4-alkyl/aryl-2H-1,2,4-triazoles-3- thione 8-12, while the acidic treatment of compounds 3-7 afforded 5-[(4,5-di- and 1,4,5-triphenylimidazol-2- yl)-3-thiomethyl]-2-alkyl/arylamino-1,3,4- thiadiazoles 13-17. Moreover, potassium hydrazinecarbothionates 18, 19 were obtained from the reaction of acyl hydrazides 1, 2 with carbon disulfides in basic media and converted into 4-amino- 1,2,4-triazole-3-thiones 20, 21 and 1,3,4-thiadiazole-2-thiols 22, 23 by the treatment with hydrazine hydrate and sulfuric acid, respectively. All newly synthesized compounds were screened for their antimicrobial activity.