139122-16-0

Basic information

• Product Name: Benzeneethanol, 2-(2-nitroethenyl)-, 1-benzoate
• Synonyms: Benzeneethanol, 2-(2-nitroethenyl)-, 1-benzoate;2-(2-nitrovinyl)phenethyl benzoate
• CAS NO: 139122-16-0
• Molecular Formula: C₁₇H₁₅NO₄
• Molecular Weight: 314.31264
• Mol File: 139122-16-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 465.8°C at 760 mmHg
• Flash Point: 196°C
• Appearance: /
• Density: 1.229g/cm³
• Vapor Pressure: 7.49E-09mmHg at 25°C
• Refractive Index: 1.615
• CAS DataBase Reference: Benzeneethanol, 2-(2-nitroethenyl)-, 1-benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneethanol, 2-(2-nitroethenyl)-, 1-benzoate(139122-16-0)
• EPA Substance Registry System: Benzeneethanol, 2-(2-nitroethenyl)-, 1-benzoate(139122-16-0)

Safety Data

• Hazardous Substances Data: 139122-16-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C17H15NO4/c19-17(16-8-2-1-3-9-16)22-13-11-15-7-5-4-6-14(15)10-12-18(20)21/h1-10,12H,11,13H2

Upstream product

• 139122-15-9 benzoic acid (2-formyl)phenethyl ester 
• 493-05-0 isochromane 
• 98-88-4 benzoyl chloride 
• 168476-58-2 2-[2-(chloromethyl)phenyl]ethylbenzoate 
• 60-12-8 2-phenylethanol 
• 75-52-5 nitromethane 

Downstream Products

• 139122-18-2 4-(2-benzoyloxyethyl)-1,3-dihydro-2H-indolin-2-one 
• 139122-19-3 4-(2'-hydroxyethyl)-1,3-dihydro-2H-indol-2-one 
• 120427-93-2 4-ethylenyl-1,3-dihydro-2H-indol-2-one 
• 120427-96-5 4-(2'-bromoethyl)-1,3-dihydro-2H-indol-2-one 
• 139122-20-6 2-(2-oxo-2,3-dihydro-1H-indol-4-yl)ethyl-4-methylbenzene-1-sulfonate 
• 91374-20-8 ropinirole hydrochloride 
• 139122-17-1 4-[2-(benzoyloxy)ethyl]-3-chloro-1,3-dihydro-2H-indolin-2-one 

Relevant articles and documents

Design, synthesis, and biological evaluation of structurally constrained hybrid analogues containing ropinirole moiety as a novel class of potent and selective dopamine D3 receptor ligands

Two series of hybrid analogues were designed, synthesized, and evaluated as a novel class of selective ligands for the dopamine D3 receptor. Binding affinities of target compounds were determined (using the method of radioligand binding assay). Compared to comparator agent BP897, compounds 2a and 2c were found to demonstrate a considerable binding affinity and selectivity for D3 receptor, and especially compound 2h was similarly potent and more selective D3R ligand than BP897, a positive reference. Thus, they may provide valuable information for the discovery and development of highly potent dopamine D3 receptor ligands with outstanding selectivity.

Indoline-2-ketone D3 receptor ligand and preparation method and application thereof

The invention discloses an indoline-2-ketone D3 receptor ligand, which is a compound as shown in the formula I or pharmaceutical salt thereof, wherein n=2 or 3; R represents H, 4-CH3, 2,3-diCH3, 2-CH3, 4-OCF3, 3-OCH3, 3,4-diCH3 or 4-Cl. In comparison with the prior art, the compound has a strong activity to a dopamine D3 receptor, is used in treating or preventing central nervous and metal diseases such as schizophrenia, Parkinson's disease, drug dependence and relapse, etc., can be used in neuroprotection, and is used as a tool drug for researching D3 receptor structure, function and diseases related to D3 receptor dysfunction.

Hexahydro-cyclohepta-pyrrole oxindole as potent kinase inhibitors

The present invention is directed to a class indolinone compounds, hexahydro-cyclohepta-pyrrole oxindoles, which are useful as protein kinase inhibitors.