139132-06-2

Basic information

• Product Name: Acetic acid, cyclopropylidene-, phenylmethyl ester
• CAS NO: 139132-06-2
• Molecular Formula: C12H12O2
• Molecular Weight: 188.226
• Mol File: 139132-06-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Acetic acid, cyclopropylidene-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, cyclopropylidene-, phenylmethyl ester(139132-06-2)
• EPA Substance Registry System: Acetic acid, cyclopropylidene-, phenylmethyl ester(139132-06-2)

Safety Data

• Hazardous Substances Data: 139132-06-2(Hazardous Substances Data)

Upstream product

• 78385-36-1 benzyloxycarbonylmethyltriphenylphosphonium bromide 
• 13837-45-1 1-ethoxy-1-cyclopropanol 
• 15097-38-8 (carbobenzyloxymethylene)triphenylphosphorane 
• 832142-14-0 2-{1-[(methylsulfonyl)oxy]cyclopropyl}acetic acid 
• 832142-17-3 1-(2,2-diethoxyethyl)cyclopropane-1-ol 
• 832142-15-1 1-(2,2-dimethoxyethyl)cyclopropan-1-ol 
• 832142-18-4 benzyl 2-(1'-mesyloxycyclopropyl)acetate 
• 5009-28-9 cyclopropanone methyl hemiacetal 
• 27374-25-0 [(1-Ethoxycyclopropyl)oxy]trimethylsilane 
• 5437-45-6 Benzyl bromoacetate 
• 100-51-6 benzyl alcohol 

Downstream Products

• 133616-14-5 benzyl 2-<1-(dibenzylamino)cyclopropyl>acetate 

Relevant articles and documents

SUBSTITUTED PYRROLIDINES AND THEIR USE

The invention discloses compounds of Formula (I) wherein R1, R2, R3, R3A, R4, and R5 are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.

COMPOUNDS THAT INHIBIT MCL-1 PROTEIN

Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Cyclopropyl building blocks for organic synthesis, part 100.[?] Advanced syntheses of cyclopropylideneacetates - Versatile multifunctional building blocks for organic synthesis

A well reproducible and inexpensive preparation of the cyclopropylideneacetates 2-4 has been developed. The key intermediate 2-(1′-mesyloxycyclopropyl)acetic acid (8), produced either from methyl phenylacetate (1) or 3,3-dimethoxypropionate (5-Me) and 3,3-diethoxypropionate (5-Et) in a sequence of Kulinkovich reductive cyclopropanation, mesylation and oxidative cleavage or cleavage and oxidation, respectively, was either converted to the benzyl ester 11b, or chlorinated (brominated) via the in situ formed acid chloride. The α-chloro- 12a and α-bromo ester 12b were dehydromesylated by treatment with triethylamine to furnish methyl 2-chloro-2-cyclopropylideneacetate (3-Me) and the 2-bromo analogue 4-Me with an overall yield of 68% (65%, 68%) and 52% (49%, 51%) respectively, starting from 1 (5-Me, 5-Et). The parent benzyl cyclopropylideneacetate 2-Bn was obtained by dehydromesylation of 11b with potassium t-butoxide in t-butyl methyl ether with an overall yield of 60% (57%, 9%) from 1 (5-Me, 5-Et).