139153-13-2

Upstream product

• 139153-07-4 [(R)-1-Benzyl-4-(2-methoxy-ethoxy)-2-phenyl-but-(Z)-ylidene]-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine 
• 59983-37-8 (+)-(S)-1-(1-benzyl-phenylethylideneamino)-2-methoxymethyl pyrrolidine 
• 54149-17-6 2-bromoethyl 2-methoxyethyl ether 
• 139153-10-9 {(R)-4-(2-Methoxy-ethoxy)-1-[(R)-3-(2-methoxy-ethoxy)-1-phenyl-propyl]-2-phenyl-butylidene}-((S)-2-methoxymethyl-pyrrolidin-1-yl)-amine 

Downstream Products

• 139153-16-5 (3R,5R)-1,7-Bis-(2-methoxy-ethoxy)-3,5-diphenyl-heptan-4-ol 

Relevant academic research and scientific papers

Diastereo- and enantioselective synthesis of α,α'-disubstituted, C2-symmetric ketones using the SAMP-/RAMP-hydrazone method

Starting from simple, symmetric ketones such as, 3-pentanone,1,3-diphenyl-2-propanone and 2,2-dimethyl-1,3-dioxan-5-one, α,α'-bisalkylation of the corresponding SAMP-hydrazones (S)-2 and (S)-8 [(S)-1 -(alkylideneamino)-2-(methoxymethyl)pyrrolidines and (S)-1-(2,2-dimethyl-1,3-dioxan-5-ylideneamino)-2-(methoxymethyl)pyrroli dines, respectively], followed by oxidative cleavage with ozone affords chiral, C2-symmetric ketones 5 and (S,S)-11 of high diastereo- and enantiomeric purity (de, ee > 98%).