1391608-80-2

Upstream product

• 1550-35-2 2,4-difluorobenzaldehyde 
• 619-45-4 4-methoxycarbonyl aniline 

Downstream Products

• 1391608-81-3 2-(2,4-difluorophenyl)spiro(cyclopropane-1,4'-1',2',3',4'-tetrahydroquinoline)-6-carboxylic acid methyl ester 
• 1391608-79-9 2'-(2,4-difluorophenyl)-N-(methylsulfonyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-quinoline]-6'-carboxamide 
• 1391608-82-4 2-(2,4-difluorophenyl)spiro(cyclopropane-1,4'-1',2',3',4'-tetrahydroquinoline)-6-carboxylic acid 

Relevant academic research and scientific papers

NOVEL TETRAHYDROQUINOLINE DERIVATIVES

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein R1 to R8, A1 to A3 have the are as described herein and compositions including the compounds.

NOVEL TETRAHYDROQUINOLINE DERIVATIVES

A compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein R1 to R8, A1 to A3 have the significance given in claim 1, can be used as AMPK modulators for treating obesity, hyperglycemia or type 2 diabetes.