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139162-43-9

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  • Factory Price OLED 99% 139162-43-9 N-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)acetamide (Tamibarotene) Manufacturer

    Cas No: 139162-43-9

  • USD $ 0.1-0.1 / Gram

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  • Xi'an Xszo Chem Co., Ltd.
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139162-43-9 Usage

General Description

Tamibarotene, also known as Am80, is a synthetic retinoid derivative and a member of the retinoid family of drugs. It is used in the treatment of acute promyelocytic leukemia (APL) and is classified as a selective retinoic acid receptor (RAR) agonist. Tamibarotene works by regulating gene expression and promoting the differentiation of promyelocytic leukemic cells into mature granulocytes, thereby inhibiting the growth of cancer cells. It has been shown to have a higher affinity for RARα and RARβ compared to other retinoids and exhibits less toxicity. Additionally, research has suggested that Tamibarotene may have potential therapeutic applications for other cancers, as well as for various dermatological conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 139162-43-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,1,6 and 2 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 139162-43:
(8*1)+(7*3)+(6*9)+(5*1)+(4*6)+(3*2)+(2*4)+(1*3)=129
129 % 10 = 9
So 139162-43-9 is a valid CAS Registry Number.

139162-43-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)acetamide

1.2 Other means of identification

Product number -
Other names Acetamide,N-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:139162-43-9 SDS

139162-43-9Relevant articles and documents

The cubane paradigm in bioactive molecule discovery: Further scope, limitations and the cyclooctatetraene complement

Houston, Sevan D.,Fahrenhorst-Jones, Tyler,Xing, Hui,Chalmers, Benjamin A.,Sykes, Melissa L.,Stok, Jeanette E.,Farfan Soto, Clementina,Burns, Jed M.,Bernhardt, Paul V.,De Voss, James J.,Boyle, Glen M.,Smith, Maree T.,Tsanaktsidis, John,Savage, G. Paul,Avery, Vicky M.,Williams, Craig M.

, p. 6790 - 6798 (2019/07/22)

The cubane phenyl ring bioisostere paradigm was further explored in an extensive study covering a wide range of pharmaceutical and agrochemical templates, which included antibiotics (cefaclor, penicillin G) and antihistamine (diphenhydramine), a smooth muscle relaxant (alverine), an anaesthetic (ketamine), an agrochemical instecticide (triflumuron), an antiparasitic (benznidazole) and an anticancer agent (tamibarotene). This investigation highlights the scope and limitations of incorporating cubane into bioactive molecule discovery, both in terms of synthetic compatibility and physical property matching. Cubane maintained bioisosterism in the case of the Chagas disease antiparasitic benznidazole, although it was less active in the case of the anticancer agent (tamibarotenne). Application of the cyclooctatetraene (COT) (bio)motif complement was found to optimize benznidazole relative to the benzene parent, and augmented anticancer activity relative to the cubane analogue in the case of tamibarotene. Like all bioisosteres, scaffolds and biomotifs, however, there are limitations (e.g. synthetic implementation), and these have been specifically highlighted herein using failed examples. A summary of all templates prepared to date by our group that were biologically evaluated strongly supports the concept that cubane is a valuable tool in bioactive molecule discovery and COT is a viable complement.

Retinobenzoic Acids. 6. Retinoid Antagonists with a Heterocyclic Ring

Eyrolles, Laurence,Kagechika, Hiroyuki,Kawachi, Emiko,Fukasawa, Hiroshi,Iijima, Tohru,et al.

, p. 1508 - 1517 (2007/10/02)

Several candidate retinoid anatgonists were designed on the basis of the ligand superfamily concept and synthesized.Retinoidal activities of these benzimidazole and benzodiazepine derivatives were examined by assay of differentiation-inducing activity on

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