139165-55-2Relevant academic research and scientific papers
Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter
Jobson, Nicola K.,Crawford, Andrew R.,Dewar, Deborah,Pimlott, Sally L.,Sutherland, Andrew
supporting information; experimental part, p. 4996 - 4998 (2010/03/31)
A stereoselective 10-step synthesis of iodophenoxy analogues of (2R,3S)-reboxetine has been developed with the aim of generating a new SPECT imaging agent for the noradrenaline transporter (NAT). In vitro testing of these compounds against various mono-am
Highly stereoselective syn-ring opening of enantiopure epoxides with nitric oxide
Wu, Wentao,Liu, Qiang,Shen, Yinglin,Li, Rui,Wu, Longmin
, p. 1653 - 1656 (2008/02/03)
Reaction of enantiopure epoxides (1) with NO occurred highly stereoselectively, affording syn-ring opened products, nitrates (2). The configuration of 2 was confirmed to be retained by determining the configuration of reduced products 1,2-glycols (4) from 2. A possible mechanism is suggested to trace out the syn-ring opening pathway.
Asymmetric Dihydroxylation of Primary Allylic Halides and a Concise Synthesis of (-)-Diepoxybutane
Vanhessche, Koen P. M.,Wang, Zhi-Min,Sharpless, K. Barry
, p. 3469 - 3472 (2007/10/02)
The asymmetric dihydroxylation (AD) of primary allylic halides is described.Enantiomeric excesses range from 40 to 98percent.Subsequent base treatment gives epoxy alcohols in high yields.This strategy is further illustrated by the synthesis of (-)-diepoxybutane, an important C4-chiral building block.
