139166-94-2

Upstream product

• 139167-09-2 2-(tert-butyldiphenylsiloxy)-1-(p-methoxyphenyl)-1-ethanol 
• 139167-13-8 (tert-butyldiphenylsiloxy)methyl p-methoxyphenyl ketone 
• 139167-24-1 1-(tert-butyldiphenylsiloxy)-2-cyclopropylidene-2-(p-methoxyphenyl)ethane 

Downstream Products

• 139167-02-5 (S)-(-)-2-(hydroxymethyl)-2-(p-methoxyphenyl)cyclobutanone 
• 139167-04-7 (R)-(+)-2-(hydroxymethyl)-2-(p-methoxyphenyl)cyclobutanone 

Relevant academic research and scientific papers

Electrophilic addition of allylic carbocations to 2-cyclopropylidene-2- arylethanols: A strategy to 3-oxabicyclo[3.2.0]heptanes

We have developed an electrophilic addition of allylic carbocations to 2-cyclopropylidene-2-arylethanols constructing carbon-carbon bonds with excellent regio- and stereoselectivities. The reaction affords 3-oxabicyclo[3.2.0]heptanes in moderate to good y

A Concise and Enantioselective Approach to Cyclobutanones by Tandem Asymmetric Epoxidation and Enantiospecific Ring Expansion of Cyclopropylidene Alcohols. An Enantiocontrolled Synthesis of (+)- and (-)-α-Cuparenones

A tandem Katsuki-Sharpless asymmetric epoxidation and enantiospecific ring expansion of 2-alkyl(or 2-aryl)-2-cyclopropylideneethanols (1a-i) afforded chiral 1-alkyl(or 1-aryl)-1-(hydroxymethyl)cyclobutanones (3a-i) in high yields and high enantiomeric excess.These compounds are potentially valuable synthons for the enantioselective creation of the quaternary carbons.Hence, this enabled us to accomplish a concise and enantioselective total synthesis of both (+)- and (-)-cuparenones (11).