139167-15-0

Basic information

• Product Name: Ethanone, 2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-phenyl-
• CAS NO: 139167-15-0
• Molecular Formula: C24H26O2Si
• Molecular Weight: 374.555
• Mol File: 139167-15-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Ethanone, 2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-phenyl-(139167-15-0)
• EPA Substance Registry System: Ethanone, 2-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-phenyl-(139167-15-0)

Safety Data

• Hazardous Substances Data: 139167-15-0(Hazardous Substances Data)

Upstream product

• 582-24-1 1-phenyl-2-hydroxyethanone 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 288-32-4 1H-imidazole 

Downstream Products

• 851164-99-3 (R,Z)-N-[2-(tert-butyldiphenylsiloxy)-1-phenylethylidene]-2-methylpropane-2-sulfinamide 
• 851165-04-3 (S,S)-tert-butanesulfinic acid [2-(tert-butyldiphenylsilyloxy)-1-cyano-1-phenylethyl]amide 
• 851165-01-0 (R,R)-tert-butanesulfinic acid [2-(tert-butyldiphenylsilyloxy)-1-cyano-1-phenylethyl]amide 
• 6321-86-4 (S)-α-phenylserine 
• 6321-86-4 (R)-α-phenylserine 
• 1394137-83-7 (S)-N-((R)-1-(tert-butyldiphenylsilyloxy)-2-phenylpropan-2-yl)-2-methylpropane-2-sulfinamide 
• 552292-08-7 Rolapitant 

Relevant articles and documents

A NK - 1 receptor antagonists of the preparation method and its intermediate

The invention relates to a preparation method of an NK-1 receptor antagonist and an intermediate thereof. The invention provides a preparation method of (5S, 8s)-8-{[1-(3, 5-bis-(trifluoromethyl)phenyl)-ethoxy]methyl}-8-phenyl-1, 7-diaza-spiro[4, 5]dec-2-one (formula I compound), which is prepared from a formula II compound, and also provides the formula II compound and a preparation method thereof. The method provided by the invention has the advantages of simple operation, mild reaction condition, high safety factor, little side reaction, high yield and high purity, lowers the production cost and operation risk, and is very suitable for large-scale industrial production. (formula II as shown in the specification).

Diastereoselective synthesis of (S)- and (R)-α-phenylserine by a sulfinimine-mediated strecker reaction

A straightforward and efficient diastereoselective synthesis of (S)- and (R)-α-phenylserine is reported. The key step involves an asymmetric Strecker reaction of a chiral N-sulfinyl ketimine, which was obtained from the commercially available 2-hydroxyace

An alternative to the Swern oxidation

A variety of alcohols have been oxidized under mild conditions by the DMSO-Ph3P·X2 complexes. The reaction does not produce any Pummerer product. A mechanism for the reaction is proposed.