1391815-07-8

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 152404-44-9 [2′,3′,5′,6′-d₄]bromophenol 
• 4165-62-2 phenol-d5 

Downstream Products

• 284474-52-8 4-hydroxy(2,3,5,6-²H₄)benzaldehyde 
• 1391815-08-9 C₁₁H₅⁽²⁾H₄NO₃ 
• 1258536-45-6 D⁴-α-cyano-4-hydroxycinnamic acid 

Relevant academic research and scientific papers

Deuterated matrix-assisted laser desorption ionization matrix uncovers masked mass spectrometry imaging signals of small molecules

D4-α-Cyano-4-hydroxycinnamic acid (D4-CHCA) has been synthesized for use as a matrix for matrix-assisted laser desorption ionization-mass spectrometry (MALDI-MS) and MALDI-MS imaging (MSI) of small molecule drugs and endogenous compounds. MALDI-MS analysis of small molecules has historically been hindered by interference from matrix ion clusters and fragment peaks that mask signals of low molecular weight compounds of interest. By using D4-CHCA, the cluster and fragment peaks of CHCA, the most common matrix for analysis of small molecules, are shifted by + 4, + 8 and + 12 Da, which expose signals across areas of the previously concealed low mass range. Here, obscured MALDI-MS signals of a synthetic small molecule pharmaceutical, a naturally occurring isoquinoline alkaloid, and endogenous compounds including the neurotransmitter acetylcholine have been unmasked and imaged directly from biological tissue sections.