1391827-01-2Relevant academic research and scientific papers
Synthesis of strained cyclic peptides via an aza-Michael-acyl-transfer reaction cascade
Rutters, Jochem P. A.,Verdonk, Yvette,De Vries, Remko,Ingemann, Steen,Hiemstra, Henk,Levacher, Vincent,Van Maarseveen, Jan H.
, p. 8084 - 8086 (2012/09/07)
A new method is presented to prepare strained lactams. Esterification of the C-terminus of a dipeptide with β-nitrostyrene or quinoline-type auxiliaries is followed by lactam formation by an intramolecular aza-Michael-acyl-transfer reaction cascade. Ultimately, the cyclic tetrapeptide cyclo[Phe-Tyr-Ala-Gly] has been prepared.
