1391827-48-7

Basic information

• Product Name: 1-(4-(tetrahydropyran-4-ylmethylaminocarbonyl)phenylsulfonyl)-3-nonadeuteriocyclopentyl indole
• CAS NO: 1391827-48-7
• Molecular Weight: 475.53
• Mol File: 1391827-48-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-(tetrahydropyran-4-ylmethylaminocarbonyl)phenylsulfonyl)-3-nonadeuteriocyclopentyl indole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-(tetrahydropyran-4-ylmethylaminocarbonyl)phenylsulfonyl)-3-nonadeuteriocyclopentyl indole(1391827-48-7)
• EPA Substance Registry System: 1-(4-(tetrahydropyran-4-ylmethylaminocarbonyl)phenylsulfonyl)-3-nonadeuteriocyclopentyl indole(1391827-48-7)

Safety Data

• Hazardous Substances Data: 1391827-48-7(Hazardous Substances Data)

Upstream product

• 1391827-45-4 2-(nonadeuteriocyclopentyl)-2-(2-nitrophenyl)acetonitrile 
• 3958-60-9 2-nitrophenylmethyl bromide 
• 7516-60-1 4-chlorosulfonylbenzoyl chloride 
• 610-66-2 2-nitro-benzeneacetonitrile 
• 1391827-47-6 4-(tetrahydropyran-4-ylmethylaminocarbonyl)phenylsulfonyl chloride 
• 1391827-46-5 3-nonadeuteriocyclopentyl indole 
• 130290-79-8 4-tetrahydropyranmethylamine 

Relevant articles and documents

Syntheses of two isotopically labeled CB1 receptor antagonists

Synthesis of deuterium-labeled CB1 receptor antagonist 2-d 9 was accomplished in three steps by alkylation of 2-nitrophenylacetonitrile with cyclopentyl-d9 bromide, reductive cyclization of the resulting secondary nitrile into the 3-cyclopentyl indole-d9 and its N-sulfonylation with corresponding p-amidosulfonyl chloride. Another, structurally related, CB1 receptor antagonist 1 was radiolabeled with carbon-14 by oxidative cleavage of 3-cyclopentyl indole followed by the ring closure of o-acyl substituted N-formylaniline with potassium cyanide-[14C], in situ reduction-elimination of the intermediate amino alcohol, and N-sulfonylation of the resulting 3-cyclopentyl indole-2-[14C]. Copyright