1391908-81-8Relevant academic research and scientific papers
Total syntheses of dichotomines A-D and the stereochemical revision of dichotomines B-D
Zhang, Qiang,Dong, Jing,Shi, Xiao-Xin,Lu, Xia
experimental part, p. 3317 - 3325 (2012/07/31)
New asymmetric total syntheses of (-)-dichotomines A-D (1-4) starting from L-tryptophan methyl ester and 2,3-O-isopropylidene-D-glyceraldehyde are described. The absolute configuration of the stereogenic center of (-)-dichotomine A (1) was reconfirmed as (S), on the basis of the X-ray crystallographic analysis of the conjugate (i.e., 17) of its methyl ester (i.e., 16) with (S)-N-tosylproline, whereas the absolute configurations of the stereogenic centers of (-)-dichotomines B-D (2-4) were revised as (R). Copyright
