1391925-57-7

Basic information

• Product Name: 2-(4-chlorobenzyl)pyrimidine
• Synonyms: 2-(4-chlorobenzyl)pyrimidine
• CAS NO: 1391925-57-7
• Molecular Weight: 204.659
• Mol File: 1391925-57-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(4-chlorobenzyl)pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorobenzyl)pyrimidine(1391925-57-7)
• EPA Substance Registry System: 2-(4-chlorobenzyl)pyrimidine(1391925-57-7)

Safety Data

• Hazardous Substances Data: 1391925-57-7(Hazardous Substances Data)

Upstream product

• 106-39-8 bromochlorobenzene 
• 1374650-43-7 2,4-dimethyl-3-(pyrimidin-2-ylmethyl)pentan-3-ol 
• 5053-43-0 2-methylpyrimidine 

Downstream Products

• 64385-81-5 (4-chlorophenyl)(pyrimidin-2-yl)methanone 

Relevant articles and documents

Base metal-catalyzed benzylic oxidation of (aryl)(heteroaryl)methanes with molecular oxygen

The methylene group of various substituted 2- and 4-benzylpyridines, benzyldiazines and benzyl(iso)quinolines was successfully oxidized to the corresponding benzylic ketones using a copper or iron catalyst and molecular oxygen as the stoichiometric oxidant. Application of the protocol in API synthesis is exemplified by the alternative synthesis of a precursor to the antimalarial drug Mefloquine. The oxidation method can also be used to prepare metabolites of APIs which is illustrated for the natural product papaverine. ICP-MS analysis of the purified reaction products revealed that the base metal impurity was well below the regulatory limit.