The bacterial translational GTPases (initiation factor IF2, elongation factors EF-G and EF-Tu and release factor RF3) are involved in all stages of translation, and evidence indicates that they bind to overlapping sites on the ribosome, whereupon GTP hydrolysis is triggered. We provide evidence ...detailed
Micrococcin-resistant mutants of Bacillus megaterium that carry mutations affecting ribosomal protein L11 have been characterised. The mutants fall into two groups. “L11-minus” strains containing an L11 gene with deletions, insertions or nonsense mutations which grow 2.5-fold slower than the w...detailed
To enhance the production of micrococcin GO5, a bacteriocin produced by Micrococcus sp. GO5, cultivation conditions and medium composition were optimized. The optimal initial pH and temperature for bacteriocin production were 7.0–9.0 and 37 °C, respectively. Micrococcus sp. GO5 displayed the h...detailed
Extensive NMR studies validate the 1978 Bycroft–Gowland hypothesis, hitherto unsupported by experimental evidence, regarding the constitution of micrococcin P1. Published synthetic work in the micrococcin area must be reinterpreted in light of these findings.detailed
Hepatitis C virus (HCV) is considered a major public health concern worldwide. Despite recent advances in curing chronic hepatitis C, unmet medical needs still remain, especially due to the high economic burden of therapies. Accordingly, our study aimed to identify affordable novel HCV inhibitor...detailed