1392008-19-3Relevant academic research and scientific papers
Asymmetric formal carbonyl-ene reactions of formaldehyde tert -butyl hydrazone with α-keto esters: Dual activation by bis-urea catalysts
Crespo-Pena, Ana,Monge, David,Martin-Zamora, Eloisa,Alvarez, Eleuterio,Fernandez, Rosario,Lassaletta, Jose M.
supporting information; experimental part, p. 12912 - 12915 (2012/09/25)
The dual activation of α-keto esters and formaldehyde tert-butyl hydrazone by BINAM-derived bis-ureas is the key to achieve high reactivity and excellent enantioselectivities in nucleophilic addition (formal carbonyl-ene reaction) to functionalized tertiary carbinols. Ensuing high-yielding diazene-to-aldehyde tranformations and subsequent derivatizations provides a direct entry to a variety of densely functionalized products.
