1392097-99-2

Upstream product

• 2873-29-2 D-glucal triacetate 
• 13265-84-4 D-glucal 
• 191593-14-3 4,6-O-di(tert-butyl)silanediyl-D-glucal 
• 99-06-9 3-Carboxyphenol 
• 79678-37-8 methyl 3-(benzyloxy)benzoate 
• 1700-30-7 (3-(benzyloxy)phenyl)methanol 
• 50765-13-4 (5-(benzyloxy)-2-iodophenyl)methanol 
• 1392097-96-9 C₄₂H₆₆O₇Si₂ 
• 1392097-93-6 1-C-dimethylsilyl-3-O-triisopropylsilyl-4,6-O-di-(tert-butyl)silanediyl-D-glucal 
• 1392097-92-5 5-benzyloxy-2-iodobenzyl pivalate 

Downstream Products

• 1392098-03-1 C₃₇H₅₈O₇Si₂ 
• 1392098-04-2 C₃₇H₅₈O₇Si₂ 

Relevant academic research and scientific papers

Synthesis and antifungal properties of papulacandin derivatives

Derivatives of an antifungal agent that targets the β-(1,3)-D-glucan synthase, papulacandin D, were synthesized and tested for activity. The papulacandin D structure contains a challenging benzannulated spiroketal unit, which is introduced in a palladiumcatalyzed cross-coupling reaction of a glycal silanolate and an aryl iodide followed by an oxidative spiroketalization. Four different variants were made, differing in the nature of the acyl side chain with respect to the length, and in the number and stereochemistry of the double bonds. Moderate biological activity was observed for the derivatives with a side chain based on palmitic acid and linoleic acid.