1392100-68-3Relevant articles and documents
Lewis acid mediated nucleophilic ring-opening of 1-Benzhydryl Azetidine-3-ol with aryl alcohols: A formal synthesis of carvedilol
Krishna Reddy,Ramamohan,Ganesh,Srinivas,Mukkanti,Madhusudhan
experimental part, p. 3468 - 3472 (2012/07/30)
Lewis acid mediated nucleophilic azetidine ring opening of 1-benzhydrylazetidine-3-ol with phenolic oxygen as nucleophile is reported. This approach was also utilized successfully to synthesize, carvedilol a β-adrenergic blocking agent.