139212-94-5

Basic information

• Product Name: Methanesulfonic acid (2R,3S,5S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester
• CAS NO: 139212-94-5
• Molecular Weight: 558.728
• Mol File: 139212-94-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Methanesulfonic acid (2R,3S,5S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Methanesulfonic acid (2R,3S,5S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester(139212-94-5)
• EPA Substance Registry System: Methanesulfonic acid (2R,3S,5S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester(139212-94-5)

Safety Data

• Hazardous Substances Data: 139212-94-5(Hazardous Substances Data)

Upstream product

• 127306-47-2 methyl-5-O-tert-butyldiphenylsilyl-2-deoxy-ribo-furanoside 
• 139212-93-4 methyl 5-O-(tert-butyldiphenylsilyl)-2-deoxy-3-O-methylsulfonyl-D-erythro-pentofuranoside 
• 7288-28-0 2,4-bis(trimethylsiloxy)-5-methylpyrimidine 

Downstream Products

• 15981-92-7 2,3'-anhydrothymidine 
• 3056-17-5 stavudin 
• 3056-17-5 1-(2,3-dideoxy-D-glycero-pent-2-enofuranosyl)thymine 
• 16053-52-4 threothymidine 

Relevant articles and documents

New synthesis of 2',3'-didehydro-2',3'-dideoxynucleosides.

The 3'-iodonucleoside 4 and the 3'-O-methylsulfonylthymidine 9 have been synthesized by condensation of silylated uracils 2 with methyl 5-O-tert-butyldiphensilyl-2,3-dideoxy-3-iodo-D-threo-pentofuran oside (3) and methyl 5-O-tert-butyldiphenylsilyl-2-deoxy-3-methylsulfonyl-D-erythro- pentofuranoside (8), respectively. The nucleoside 4 and 9 produced the corresponding 2',3'-didehydro-2',3'-dideoxynucleosides 5 in an elimination reaction on treatment with sodium methoxide. The compounds 5b showed no antiviral activity against HIV-1.