1392129-83-7Relevant academic research and scientific papers
Click fleximers: A modular approach to purine base-expanded ribonucleoside analogues
St. Amant, André H.,Bean, Leslie A.,Guthrie, J. Peter,Hudson, Robert H. E.
supporting information; experimental part, p. 6521 - 6525 (2012/09/08)
The synthesis of nucleoside analogues incorporating 4-(5-pyrimidinyl)-1,2, 3-triazole aglycons as expanded purine nucleobase mimics were accessed using the copper-catalyzed azide-alkyne Huisgen cycloaddition between a ribosyl azide and 5-alkynylpyrimidines. Depending on the nature of the alkyne employed, other nucleoside analogues that possess fluorescence or potential metal-binding properties were prepared. Computational studies were undertaken on the purine analogues and indicate that the heterocycles of the unfused nucleobase prefer a coplanar arrangement and the anti-glycosidic conformer is favoured in most instances.
