1392149-64-2Relevant academic research and scientific papers
Enantioselective decarboxylative aldol addition of β-ketoacids to isatins catalyzed by binaphthyl-modified organocatalyst
Suh, Chang Won,Chang, Chul Woo,Choi, Keon Woong,Lim, Young Jo,Kim, Dae Young
, p. 3651 - 3654 (2013/07/05)
The catalytic enantioselective decarboxylative aldol addition reaction of isatins with β-ketoacids promoted by chiral bifunctional organocatalysts have been developed, allowing facile synthesis of the corresponding chiral 3-hydroxy-3-phenacyloxindole deri
Enantioselective construction of 3-hydroxy oxindoles via decarboxylative addition of β-ketoacids to isatins
Zhong, Fangrui,Yao, Weijun,Dou, Xiaowei,Lu, Yixin
supporting information; experimental part, p. 4018 - 4021 (2012/09/21)
The first highly enantioselective decarboxylative addition of β-ketoacids to isatins mediated by a bifunctional tertiary amine-thiourea catalyst has been developed, allowing facile synthesis of biologically important 3-hydroxy oxindoles in good yields and excellent enantioselectivities. The method reported represents a valuable approach of utilizing β-ketoacids as synthetic equivalents of aryl/alkyl methyl ketone enolates.
