1392197-75-9Relevant academic research and scientific papers
Synthesis and evaluation of new β-carboline-3-(4-benzylidene)- 4H-oxazol-5-one derivatives as antitumor agents
Savariz, Franciele Cristina,Foglio, Mary Ann,De Carvalho, Joao Ernesto,Ruiz, Ana Lucia T.G.,Duarte, Marta C.T.,Da Rosa, Mauricio Ferreira,Meyer, Emerson,Sarragiotto, Maria Helena
, p. 6100 - 6113 (2012)
In the present work, we report the synthesis and in vitro anticancer and antimicrobial activity evaluation of a new series of 1-substituted-β- carboline derivatives bearing a 4-benzylidene-4H-oxazol-5-one unity at C-3. The compound 2-[1-(4- methoxyphenyl)-9H-β-carbolin-3-yl]-4-(benzylidene)-4H- oxazol-5-one (11) was the most active derivative, exhibiting a potent cytotoxic activity against glioma (U251), prostate (PC-3) and ovarian (OVCAR-03) cancer cell lines with IC50 values of 0.48, 1.50 and 1.07 μM, respectively. An in silico study of the ADME properties of the novel synthesized β-carboline derivatives was also performed.
