1392203-75-6

Upstream product

• 106-96-7 propargyl bromide 
• 1286196-72-2 (S)-2-[2-(p-tolylsulfinyl)phenyl]acetonitrile 

Downstream Products

• 1392204-46-4 (R)-2-(prop-2-ynyl)-2-[2-(p-tolylsulfenyl)phenyl]pent-4-enamide 
• 1392204-50-0 [2R,3aS]-5-oxo-2-[2-(p-tolylsulfenyl)phenyl]-1,2,3,3a,4,5-hexahydropentalene-2-carboxamide 
• 1392204-25-9 (R)-2-phenyl-2-(prop-2-ynyl)-pent-4-enenitrile 
• 1392204-29-3 [2R,3aR]-5-oxo-2-phenyl-1,2,3,3a,4,5-hexahydropentalene-2-carbonitrile 
• 1392204-28-2 [2R,3aS]-5-oxo-2-phenyl-1,2,3,3a,4,5-hexahydropentalene-2-carbonitrile 

Relevant academic research and scientific papers

Asymmetric intramolecular Pauson-Khand reaction mediated by a remote sulfenyl or sulfinyl group

In this work, we report the use of the asymmetric intramolecular Pauson-Khand reactions of 4-aryl-4-cyano-1,6-enynes for obtaining enantiomerically enriched bicyclo[3.3.0]octenones, and the influence of both the quaternary stereocenter and the sulfur functions located at ortho-position of the aryl group, on their stereoselectivity and reactivity. The sulfenyl derivatives bearing substituted or unsubstituted triple bonds and mono- and disubstituted alkene moieties afford bicyclo[3.3.0]octenones in high yields with complete diastereocontrol. These results are explained by assuming the association of the lone electron pair at sulfur to the Co-alkyne complexes.