1392205-25-2Relevant academic research and scientific papers
Exploring the effect of N-substitution in nor-lobelane on the interaction with VMAT2: Discovery of a potential clinical candidate for treatment of methamphetamine abuse
Zheng, Guangrong,Horton, David B.,Penthala, Narsimha Reddy,Nickell, Justin R.,Culver, John P.,Deaciuc, Agripina G.,Dwoskin, Linda P.,Crooks, Peter A.
, p. 564 - 568 (2013)
A series of N-substituted lobelane analogues was synthesized and evaluated for their [3H]dihydrotetrabenazine binding affinity at the vesicular monoamine transporter and for their inhibition of vesicular [ 3H]dopamine uptake. Compound 19a, which contains an N-1,2(R)-dihydroxypropyl group, had been identified as a potential clinical candidate for the treatment of methamphetamine abuse.
