1392205-75-2Relevant academic research and scientific papers
A simple and effective approach to the synthesis of isoquinoline derivatives under solvent-free conditions
Hossaini, Zinatossadat,Rostami-Charati, Faramarz,Firoziyan, Somayeh,Sabbaghan, Maryam,Khalilzadeh, Mohammad A.
experimental part, p. 503 - 508 (2012/08/29)
An efficient synthesis of dialkyl pyrrolo[2,1-a]isoquinoline-2,3- dicarboxylates, pyrrolo[1,2-a]quinoline-1,2- dicarboxylates and indolizines is described via one-pot reactions of isoquinoline, quinoline or pyridine and phenacyl bromids with dialkyl acetylenedicarboxylates or diaryloylacetylene under solvent-free conditions at 50°C. The mild reaction conditions and high yields of the products exhibit the good synthetic advantage of these methods.
