1392228-32-8

Basic information

• Product Name: 2,7-dimethyl-9-(4-nitrophenyl)-xanthen-9-ol
• Synonyms: 2,7-dimethyl-9-(4-nitrophenyl)-xanthen-9-ol
• CAS NO: 1392228-32-8
• Molecular Weight: 347.37
• Mol File: 1392228-32-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,7-dimethyl-9-(4-nitrophenyl)-xanthen-9-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,7-dimethyl-9-(4-nitrophenyl)-xanthen-9-ol(1392228-32-8)
• EPA Substance Registry System: 2,7-dimethyl-9-(4-nitrophenyl)-xanthen-9-ol(1392228-32-8)

Safety Data

• Hazardous Substances Data: 1392228-32-8(Hazardous Substances Data)

Upstream product

• 1579-40-4 1,1'-oxybis(4-methyl-benzene) 
• 62-23-7 4-nitro-benzoic acid 

Downstream Products

• 1411683-89-0 1-(DMPx)-2-hydroxy-propanol 
• 1392228-37-3 C₃₄H₃₅N₃O₁₀ 
• 1411689-69-4 5'-O-DMPx-2-O-Me-uridine 
• 1411688-32-8 5'-O-DMPx-thymidine 

Relevant articles and documents

Scalable synthesis of substituted 2,7-dimethyl-9-phenylxanthen-9-ol (DMPx-OH): Useful for the preparation of crystalline 5′-O-DMPx-protected nucleosides

A convenient single-step synthesis of several 2,7-dimethyl-9-phenylxanthen- 9-ol (DMPx-OH) analogs has been accomplished using a Friedel-Crafts reaction. Treatment of various DMPx-OH with unprotected 2′-O-methoxyethyl- ribonucleosides (MOE) in the presence of B(C6F5) 3, as a Lewis Acid catalyst, furnished 5′-O-protected derivatives of 2′-MOE-ribonucleosides in good yields. The deprotection of the DMPx groups was accomplished by acid hydrolysis under very mild conditions. Among the five DMPx analogs synthesized, the 2,7-dimethyl-9-(4-nitrophenyl) xanthene-9-yl group furnished crystalline products enabling non-chromatographic isolation of 5′-O-protetced nucleosides.