1392229-25-2Relevant academic research and scientific papers
A scalable synthesis of a hydroxamic acid LpxC inhibitor
Fei, Zhongbo,Kong, Weiyong,Wang, Huaimin,Peng, Jianbiao,Sun, Feng,Yin, Yueyan,Bajwa, Joginder,Jiang, Xinglong
, p. 1436 - 1441 (2012/11/07)
A short and scalable synthesis of chiral hydroxamic acid 1, a LpxC inhibitor, is described. This work discloses a novel diastereoselective addition of 2-nitropropane-generated lithium salt to tert-butanesulfinimine. Moreover, the impurity profiles of reac
