1392279-99-0

Basic information

• Product Name: C₄₃H₃₈ClN₅O₃
• Synonyms: C₄₃H₃₈ClN₅O₃
• CAS NO: 1392279-99-0
• Molecular Weight: 708.259
• Mol File: 1392279-99-0.mol

Chemical Properties

• CAS DataBase Reference: C₄₃H₃₈ClN₅O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₃H₃₈ClN₅O₃(1392279-99-0)
• EPA Substance Registry System: C₄₃H₃₈ClN₅O₃(1392279-99-0)

Safety Data

• Hazardous Substances Data: 1392279-99-0(Hazardous Substances Data)

Upstream product

• 1392280-06-6 C₂₄H₂₄N₄ 
• 53-86-1 [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid 
• 26254-35-3 5-bromoacenaphthylene-1,2-dione 
• 82-86-0 acenaphthene quinone 
• 151447-45-9 3-bromoacenaphtho[1,2-b]quinoxaline 

Relevant articles and documents

An off-on COX-2-specific fluorescent probe: Targeting the golgi apparatus of cancer cells

Identifying cancer cells and quantifying cancer-related events in particular organelles in a rapid and sensitive fashion are important for early diagnosis and for studies on pathology and therapeutics of cancers. Herein a smart off-on cyclooxygenase-2-specific fluorescence probe (ANQ-IMC-6), able to report the presence of cancer cells and to image Golgi-related events, has been designed and evaluated. Cyclooxygenase-2 (COX-2) has been used as imaging target in the probe design, since this enzyme is a biomarker of virtually all cancer cell lines. In the free state in aqueous solution, ANQ-IMC-6 mainly exists in a folded conformation where probe fluorescence is quenched through photoinduced electron transfer between the fluorophore acenaphtho[1,2-b]quinoxaline (ANQ) and the recognition group, indomethacin (IMC). Fluorescence is turned on, by restraining the photoinduced electron transfer, when ANQ-IMC-6 is forced to adopt the unfolded state following binding to COX-2 in the Golgi apparatus of cancer cells. ANQ-IMC-6 provides high signal-to-background staining and has been successfully used to rapidly differentiate cancer cells from normal cells when using flow cytometry and one- and two-photon fluorescence microscopic imaging. Furthermore, ANQ-IMC-6 may be able to visualize dynamic changes of the Golgi apparatus during cancer cell apoptosis, with possible application to early diagnosis.

TWO-PHOTON FLUORESCENT PROBE USING NAPHTHALENE AS MATRIX AND PREPARATION METHOD AND USE THEREOF

The present invention provides a novel category of naphthalene-based two-photon fluorescent probes having a general formula I, wherein: X is selected from the X1, X2, X3 and X4; The mentioned two-photon fluorescent probes have a low fluorescence background in the non-tumor cells and tissues, and have a strong and specific fluorescent signal in the tumor cells and tissues. These probes have a certain level of water-solubility, while having good membrane permeability. In addition, they have a bigger effective two-photon absorption cross section. The compounds of the present invention also have a lower biotoxicity, phototoxicity and photobleaching. There is sufficient difference between the spectral range thereof and that of a biological sample.