1392322-32-5

Basic information

• Product Name: 1-(9H-carbazol-4-yloxy)-3-chloropropan-2-yl N-[2-(2-methoxyphenoxy)ethyl]carbamate
• Synonyms: 1-(9H-carbazol-4-yloxy)-3-chloropropan-2-yl N-[2-(2-methoxyphenoxy)ethyl]carbamate
• CAS NO: 1392322-32-5
• Molecular Weight: 468.937
• Mol File: 1392322-32-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(9H-carbazol-4-yloxy)-3-chloropropan-2-yl N-[2-(2-methoxyphenoxy)ethyl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(9H-carbazol-4-yloxy)-3-chloropropan-2-yl N-[2-(2-methoxyphenoxy)ethyl]carbamate(1392322-32-5)
• EPA Substance Registry System: 1-(9H-carbazol-4-yloxy)-3-chloropropan-2-yl N-[2-(2-methoxyphenoxy)ethyl]carbamate(1392322-32-5)

Safety Data

• Hazardous Substances Data: 1392322-32-5(Hazardous Substances Data)

Upstream product

• 52602-39-8 9H-carbazol-4-ol 
• 1836-62-0 2-(2-methoxy-phenoxy)-ethylamine 
• 1392322-33-6 3-((9H-carbazol-4-yloxy)methyl)-3-chloropropane-2-yl phenyl carbonate 
• 1187921-93-2 1-(9H-carbazol-4-yloxy)-3-chloropropan-2-ol 

Downstream Products

• 180987-80-8 5-(((9H-carbazol-4-yl)oxy)methyl)-3-(2-(2-methoxyphenoxy)ethyl)oxazolidin-2-one 

Relevant articles and documents

Convenient synthesis of Carvedilol utilizing 3-(9H-carbazol-4-yloxy)-1- chloropropan-2-yl phenyl carbonate as a key intermediate

Convenient synthesis of pharmaceutically important moiety Carvedilol, 1 (β-adrenergic blocking agent) has been reported utilizing 3-(9H-carbazol-4-yloxy)-1-chloropropan-2-yl phenyl carbonate 8 as a key intermediate. The synthetic scheme involves the reaction of intermediate 8 with 2-(2-methoxy phenoxy)- ethanamine 5 by using N,N-Dimethyl-4-aminopyridine (DMAP) in N,N-dimethylformamide (DMF) which yield 3-(2-(2- methoxyphenoxy)ethyl)-5- ((9H-carbazol-4-yloxy)methyl)oxazolidin- 2-one 7 via 1-(9H-carbazol-4-yloxy)-3- chloropropan-2-yl 2- (2-methoxyphenoxy)ethylcarbamate 6. The resulted compound 7 has further been converted to the required Carvedilol and this approach could be useful for the preparation of many β-amino alcohols without formation of Impurity B.