139244-50-1Relevant articles and documents
Aminolysis of aryl ester using tertiary amine as amino donor via c-o and c-n bond activations
Bao, Yong-Sheng,Zhaorigetu, Bao,Agula, Bao,Baiyin, Menghe,Jia, Meilin
, p. 803 - 808 (2014/04/03)
An aminolysis reaction between various aryl esters and inert tertiary amines by C-O and C-N bond activations has been developed for the selective synthesis of a broad scope of tertiary amides under neutral and mild conditions. The mechanism may undergo the two key steps of oxidative addition of acyl C-O bond in parent ester and C-N bond cleavage of tertiary amine via an iminium-type intermediate.
Antimycobacterial Activity of a Series of Pyrazinoic Acid Esters
Cynamon, Michael H.,Klemens, Sally P.,Chou, Tso-Sheng,Gimi, Rayomand H.,Welch, John T.
, p. 1212 - 1215 (2007/10/02)
A series of pyrazinoic acid esters has been prepared and evaluated for in vitro antimycobacterial activity.Several of the pyrazinoate esters have substantially better activity than the first-line antituberculous agent pyrazinamide against susceptible isolates of Mycobacterium tuberculosis as well as activity against pyrazinamide-resistant isolates.The minimal inhibitory concentrations (MICs) were lower for each organism and at each pH than the MICs for pyrazinamide.The esters have activity against Mycobacterium bovis and Mycobacterium kansasii, two species resistant to pyrazinamide, but not against Mycobacterium avium complex.
