1392444-99-3Relevant academic research and scientific papers
New quinoline-5,8-dione and hydroxynaphthoquinone derivatives inhibit a chloroquine resistant Plasmodium falciparum strain
Hussain, Hidayat,Specht, Sabine,Sarite, Salem R.,Hoerauf, Achim,Krohn, Karsten
experimental part, p. 936 - 942 (2012/10/08)
We report on the design, synthesis, and in vitro evaluation of new quinoline-5,8-dione and hydroxynaphthoquinone derivatives. The synthesized compounds were evaluated for in vitro antimalarial activity against Plasmodium falciparum. Of the 15 compounds, 7a-c, 8a, 9b, 11, and 15 were effective in growth inhibition with IC50 values of below 5 μM.
