139255-61-1Relevant articles and documents
USE OF ATOM-TRANSFER RADICAL CYCLIZATIONS AS AN EFFICIENT ENTRY INTO A NEW "SEROTONERGIC" AZANORADAMANTANE
Flynn, Daniel L.,Becker, Daniel P.,Nosal, Roger,Zabrowski, Daniel L.
, p. 7283 - 7286 (2007/10/02)
A route to azanoradamantanes is described which makes use of an atom-transfer radical cyclization to afford 3-azabicycloocatanes 3A and 3B.Subsequent elaboration of exo-allylamine functionality, followed by cyclization of the endo-hydroxymethyl intermediate 9, affords the new azanoradamantanes 11 and 4.This new azatricyclic system is useful for producing serotonin 5-HT3 antagonists and 5-HT4 agonists. Key words: Azanoradamantane; 3-azabicyclooctane; serotonin