139257-77-5

Basic information

• Product Name: 14-hydroxy-4,14-retro-retinol
• Synonyms: 14-hydroxy-4,14-retro-retinol
• CAS NO: 139257-77-5
• Molecular Formula: C20H30O2
• Molecular Weight: 302.451
• Mol File: 139257-77-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 470.8°Cat760mmHg
• Flash Point: 210.8°C
• Appearance: /
• Density: 1.015g/cm³
• Vapor Pressure: 7.65E-11mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: 14-hydroxy-4,14-retro-retinol(CAS DataBase Reference)
• NIST Chemistry Reference: 14-hydroxy-4,14-retro-retinol(139257-77-5)
• EPA Substance Registry System: 14-hydroxy-4,14-retro-retinol(139257-77-5)

Safety Data

• Hazardous Substances Data: 139257-77-5(Hazardous Substances Data)

Usage

Hazard

A reproductive hazard.

InChI:InChI=1/C20H30O2/c1-15(8-6-9-17(3)19(22)14-21)11-12-18-16(2)10-7-13-20(18,4)5/h6,8-12,19,21-22H,7,13-14H2,1-5H3/b8-6+,15-11+,17-9+,18-12+

Upstream product

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Relevant articles and documents

Studies on the apoptotic activity of natural and synthetic retinoids: Discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells

New terphenyl derivatives have been synthesized and tested for their effect on cell survival in serum-free cultures. These compounds protected HL60 cells from death and supported their growth with an activity higher than that of the natural 14-hydroxy-retro-retinol. Terphenyls 26 and 28 also possess antiapoptotic activity on neuronal cells, proving them as possible candidates for the treatment of neurodegenerative and ischemic diseases.

Practical total syntheses of (R)-(+)- and (S)-(-)-14-hydroxy-4,14-retro- retinol

Practical and facile total syntheses of the remarkably unstable (R)-(+)- 14-hydroxy-4, 14-retro-retinol [(R)-14HRR] 1 and of its enantiomer 2 have been achieved via an acid-catalyzed dehydration reaction of the respective tetraeneol intermediates 10 and i