1392592-75-4Relevant academic research and scientific papers
Synthesis of homotaurine and 1-substituted homotaurines from α,β-unsaturated nitriles
Ma, Yunhai,Xu, Jiaxi
, p. 2225 - 2230 (2012/09/22)
Homotaurine and a series of 1-substituted homotaurines were readily synthesized in satisfactory to good yields via the Michael addition of thioacetic acid to aliphatic and aromatic α,β-unsaturated nitriles followed by lithium aluminum hydride mediated reduction and performic acid oxidation. The synthesis of 1,1-disubstituted homotaurines was attempted with β,β-disubstituted acrylonitriles as starting materials but failed due to steric hindrance. The current process is an efficient method for the synthesis of 1-substituted homotaurines. Georg Thieme Verlag Stuttgart New York.
