139266-61-8Relevant articles and documents
2,3-Bifunctionalized quinoxalines: Synthesis, DNA interactions and evaluation of anticancer, anti-tuberculosis and antifungal activity
Waring, Michael J.,Ben-Hadda, Taibi,Kotchevar, Ann T.,Ramdani, Abdelkrim,Touzani, Rachid,Elkadiri, Sghir,Hakkou, Abdelkader,Bouakka, Mohamed,Ellis, Tom
, p. 641 - 656 (2007/10/03)
A variety of 2,3-bifunctionalized quinoxalines (6-14) have been prepared by the condensation of 1,6-disubstituted-hexan-1,3,4,6-tetraones (1-4) with o-phenylenediamine, (R,R)-1,2-diaminocyclohexane and p-nitro-o-phenylenediamine. It is concluded that strong intramolecular N-H-O bonds in the favoured keto-enamine form may be responsible for the minimal biological activities observed in DNA footprinting, anti-tubercular, anti-fungal and anticancer tests with these hyper π-conjugated quinoxaline derivatives. However, subtle alteration by addition of a nitro group affecting the charge distribution confers significant improvements in biological effects and binding to DNA.
1.3.4.6-Tetracarbonyl Compounds. I. The Novel Synthesis of 1,6-Diaryl-3,4-dihydroxy-hexa-2,4-diene-1,6-diones from 5-Aryl-furan-2,3-diones
Kozminykh, Vladislav O.,Konshina, Larisa O.,Igidov, Nazim M.
, p. 714 - 716 (2007/10/02)
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