139286-07-0

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 58050-61-6 4-(4-chlorobenzyl)-6-phenylpyridazin-3(2H)-one 
• 39499-57-5 4H,5H-6-phenoxyphenylpyridazin-3(2H)-one 
• 158502-59-1 4-(4-Chloro-benzyl)-6-(4-phenoxy-phenyl)-2H-pyridazin-3-one 
• 139285-97-5 4-(4-Chloro-benzoyl)-6-phenyl-2H-pyridazin-3-one 

Relevant academic research and scientific papers

Synthesis and Chemistry of 4-Aroyl-3-oxo- and 3-Chloropyridazine Derivatives

4H,5H-6-Phenyl (1a) and 6-p-phenoxyphenyl (1b) pyridazin-3(2H)-ones were reacted with aromatic aldehydes to give 4-arylmethylpyridazin-3(2H)-ones (2a-g).Oxidation of (2a-g) with various oxidising agents (selenium dioxide in ethanol or chromium trioxide in acetic acid) gave 4-aroyl-6-arylpyridazin-3(2H)-ones (3a-g).Chlorination of (3a-g) with phosphorus oxychloride afforded 4-aroyl-6-aryl-3-chloropyridazine (4a-g). 1H-3-Aryl-5-phenylpyrazolopyridazines (5a-d) were obtained by heating (4a-d) with excess hydrazine hydrate.Hydroxyamination of (3e-g) with hydroxylamine gave aryl-4(6-p-phenoxyphenyl-2,3-dihydro-3-oxo)pyridazinyl oxime (6a-c).Silylation of oximes (6b and 6c) gave (7a and 7b) as acyclic compound instead of the expected seven-membered-ring compound (8).

Novel Synthesis of 4-Aroyl-6-phenylpyridazin-3(2H)-ones

4-Aroyl-6-phenylpyridazin-3(2H)-ones, 1H NMR Spectra4-Aroyl-6-phenylpyridazin-3(2H)-ones (4a-c) were synthesized by the oxidation of the corresponding 4-arylmethyl-6-phenylpyridazin-3(2H)-ones (3a-c) using sodium dichromate in glacial acetic acid.The reac