139286-80-9Relevant academic research and scientific papers
Novel Approach to the Ring-Opening of 4-Isoxazolines: One-Pot Synthesis of α,β-Enones
Chiacchio, Ugo,Liguori, Angelo,Rescifina, Antonio,Romeo, Giovanni,Rossano, Flavia,et al.
, p. 123 - 132 (2007/10/02)
Treatment of 4-isoxazoline derivatives with methyl iodide affords α,β-enones in excellent yields.The novel rearrangement pathway, through an intermediate isoxazolinium salt, is interpretable on the basis of the base removal of the hydrogen atom at N-CH3 group.
