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Rimocidin, also known as Rimofungin, is an investigational antifungal drug that belongs to the echinocandin class. It is derived from the fermentation of Aspergillus spp. and exhibits potent activity against various Candida species, including Candida albicans, Candida glabrata, and Candida krusei. Rimocidin works by inhibiting the synthesis of β-(1,3)-D-glucan, an essential component of the fungal cell wall, leading to cell death. Although it has shown promise in preclinical studies and early-phase clinical trials, Rimocidin is not yet approved for use in humans due to concerns about its safety profile and potential side effects, such as hepatotoxicity. Further research and development are needed to determine its potential role in treating invasive fungal infections.

1393-12-0

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1393-12-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1393-12-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,3,9 and 3 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1393-12:
(6*1)+(5*3)+(4*9)+(3*3)+(2*1)+(1*2)=70
70 % 10 = 0
So 1393-12-0 is a valid CAS Registry Number.
InChI:InChI=1/C39H61NO15/c1-3-13-25-16-10-8-6-5-7-9-11-17-26(53-38-35(47)33(40)34(46)31(22-41)54-38)19-30-32(36(48)49)29(45)21-39(51,55-30)20-24(43)15-12-14-23(42)18-28(44)27(4-2)37(50)52-25/h5-11,17,24-35,38,41,43-47,51H,3-4,12-16,18-22,40H2,1-2H3,(H,48,49)/b6-5+,9-7+,10-8+,17-11+/t24?,25-,26?,27?,28?,29?,30?,31+,32?,33-,34+,35-,38+,39?/m0/s1

1393-12-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name (1S,3R,4E,6E,8E,10E,13R,16S,17R,23S,25R,27S,28R)-3-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-16-ethyl-17,23,25,27-tetrahydroxy-15,19-dioxo-13-propyl-14,29-dioxabicyclo[23.3.1]nonacosa-4,6,8,10-tetraene-28-carboxylic acid

1.2 Other means of identification

Product number -
Other names Rimocidin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1393-12-0 SDS

1393-12-0Upstream product

1393-12-0Downstream Products

1393-12-0Related news

ArticleStarter Unit Choice Determines the Production of Two Tetraene Macrolides, Rimocidin (cas 1393-12-0) and CE-108, in Streptomyces diastaticus var. 10809/01/2019

Streptomyces diastaticus var. 108, a newly isolated strain [1], produces two closely related tetraene macrolides (rimocidin and CE-108) as well as oxytetracycline. A region of 19,065 base pairs of DNA from the S. diastaticus var. 108 genome was isolated, sequenced, and characterized. Ten complet...detailed

1393-12-0Relevant academic research and scientific papers

POLYENE ANTIBIOTICS, COMPOSITIONS CONTAINING SAID ANTIBIOTICS, METHOD AND MICRO-ORGANISMS USED TO OBTAIN SAME AND APPLICATIONS THEREOF

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Page/Page column 5; 24; 27; 47, (2008/06/13)

Abstract: The invention relates to novel polyenes having formula (I), wherein: R1 represents alkyl C1-C3; and R2 represents a functional group selected from CH3- or CONH2- (methyl- or primary amide-). The aforementioned polyenes have a biocide action on organisms comprising cell membranes that contain ergosterol, e.g., fungi or parasites. Said compounds can be obtained using a method that consists in cultivating a producing micro-organism under conditions that enable the production thereof. In addition, the invention also relates to a mechanism for the in vitro production of amidated polyenes, consisting in incubating carboxylated polyenes with cell-free extracts (or proteinaceous fractions) of the producers of same in the presence of ATP/Mg++ and an amide-group donor compound (preferably glutamine).

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