1393-38-0

Basic information

• Product Name: subtilin
• Synonyms: subtilin;Nsc404853
• CAS NO: 1393-38-0
• Molecular Formula: C148H227 N39 O38 S5
• Molecular Weight: 3321.44
• Mol File: 1393-38-0.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: subtilin(CAS DataBase Reference)
• NIST Chemistry Reference: subtilin(1393-38-0)
• EPA Substance Registry System: subtilin(1393-38-0)

Safety Data

• Hazardous Substances Data: 1393-38-0(Hazardous Substances Data)

Usage

Uses

Food preservative.

InChI:InChI=1/C148H227N39O38S5/c1-21-74(13)114(144(220)161-77(16)120(196)169-93(148(224)225)41-30-33-51-151)182-127(203)89(40-29-32-50-150)165-136(212)103-66-228-80(19)117-146(222)180-105(138(214)174-99(59-109(155)190)133(209)179-103)68-229-79(18)116(145(221)175-97(56-72(9)10)134(210)184-117)183-128(204)91(44-47-108(154)189)167-130(206)96(55-71(7)8)172-132(208)98(57-82-35-24-23-25-36-82)173-137(213)104-67-227-78(17)115(142(218)158-61-110(191)159-75(14)119(195)170-94(53-69(3)4)129(205)166-90(43-46-107(153)188)126(202)163-86(22-2)123(199)178-104)185-143(219)113(73(11)12)181-140(216)102-65-230-81(20)118(147(223)187-52-34-42-106(187)141(217)157-62-111(192)162-102)186-139(215)101-64-226-63-100(135(211)168-92(45-48-112(193)194)124(200)160-76(15)121(197)171-95(54-70(5)6)131(207)177-101)176-125(201)88(39-28-31-49-149)164-122(198)85(152)58-83-60-156-87-38-27-26-37-84(83)87/h22-27,35-38,60,69-75,78-81,85,88-106,113-118,156H,15-16,21,28-34,39-59,61-68,149-152H2,1-14,17-20H3,(H2,153,188)(H2,154,189)(H2,155,190)(H,157,217)(H,15

Related news

Parameter identification for stochastic hybrid systems using randomized optimization: A case study on subtilin (cas 1393-38-0) production by Bacillus subtilis09/10/2019

In this paper we study the parameter identification problem for a stochastic hybrid model of the production of the antibiotic subtilin by the bacterium B. subtilis. We pursue a simulation-based approach, in which the fit of candidate parameter values is evaluated by comparing simulated model tra...detailed

Sequence-specific resonance assignment and conformational analysis of subtilin (cas 1393-38-0) by 2D NMR09/09/2019

Subtilin, a 32-amino acid peptide with potent antimicrobial activity, has been isolated from Bacillus subtilis ATCC6633. The chemical structure has been confirmed by the unambiguous sequence-specific assignment of its 1H NMR spectrum. Detailed NMR analysis revealed that subtilin is a rather flex...detailed

Heterologous expression and purification of SpaB involved in subtilin (cas 1393-38-0) biosynthesis09/08/2019

Lantibiotic peptides contain thioether bridges termed lanthionines that are putatively generated by dehydration of Ser and Thr residues followed by Michael addition of cysteine residues within the peptide. The LanB and LanC proteins have been proposed to catalyze the dehydration and formation of...detailed

Activation of subtilin (cas 1393-38-0) precursors by Bacillus subtilis extracellular serine proteases subtilisin (AprE), WprA, and Vpr09/07/2019

The maturation of the peptide antibiotic (lantibiotic) subtilin in Bacillus subtilis ATCC 6633 includes posttranslational modifications of the propeptide and proteolytic cleavage of the leader peptide. To identify subtilin processing activities, we used antimicrobial inactive subtilin precursors...detailed

Studies of the subtilin (cas 1393-38-0) leader peptide as a translocation signal in Escherichia coli K1209/06/2019

Subtilin is an antimicrobial peptide of the lantibiotic family that is produced by Gram-positive Bacillus subtilis, and its biosynthesis involves expression of presubtilin which consists of a leader segment and a mature segment. The leader segment is unlike a typical sec-type general secretion s...detailed

Maturation and processing of SpaI, the lipoprotein involved in subtilin (cas 1393-38-0) immunity in Bacillus subtilis ATCC 663309/04/2019

SummarySpaI is a small lipoprotein that provides Bacillus subtilis with autoimmunity against the lantibiotic subtilin. We have investigated the maturation of SpaI through the lipoprotein biosynthesis pathway, and analyzed the consequences of maturations in the acylation of the target lipobox in ...detailed

Autoregulation of subtilin (cas 1393-38-0) biosynthesis in Bacillus subtilis: the role of the spa-box in subtilin (cas 1393-38-0)-responsive promoters09/03/2019

The production of the type I antimicrobial peptide (AMP) subtilin by Bacillus subtilis is regulated in a cell-density-dependent manner [Kleerebezem M, de Vos WM, Kuipers OP. The lantibiotics nisin and subtilin act as extracellular regulators of their own biosynthesis. In: Dunny GM, Winans SC, ed...detailed

Identification of unstructured model for subtilin (cas 1393-38-0) production through Bacillus subtilis using hybrid genetic algorithm09/02/2019

Subtilin production is favorable when Bacillus subtilis 168 is subjected to stress condition such as nutrient scarcity. A mathematical model underlying such growth process has immense applicability in determining the optimal operating conditions at industrial scale. We present this work with mul...detailed