139301-91-0

Upstream product

• 90026-55-4 (3R,4R)-(+)-cis-dimethyl-(γ)-butyrolactone 
• 1750-73-8 2,2-dimethyl-3-oxo-butanal 
• 139301-89-6 N-{(S)-[(2S,4R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-6-((S)-2,3-dimethoxy-propyl)-5,5-dimethyl-tetrahydro-pyran-2-yl]-methoxy-methyl}-2-hydroxy-2-((2R,4R,5R,6R)-2-methoxy-5,6-dimethyl-4-phenylselanylmethyl-tetrahydro-pyran-2-yl)-acetamide 
• 139301-88-5 N-{(S)-[(2S,4R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-6-((S)-2,3-dimethoxy-propyl)-5,5-dimethyl-tetrahydro-pyran-2-yl]-methoxy-methyl}-2-((4S,5R,6R)-5,6-dimethyl-4-phenylselanylmethyl-5,6-dihydro-4H-pyran-2-yl)-2-hydroxy-acetamide 
• 139301-85-2 N-{(S)-[(2S,4R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-6-((S)-2,3-dimethoxy-propyl)-5,5-dimethyl-tetrahydro-pyran-2-yl]-methoxy-methyl}-2-((4S,5R,6R)-5,6-dimethyl-4-phenylselanylmethyl-5,6-dihydro-4H-pyran-2-yl)-2-oxo-acetamide 
• 139301-78-3 (2R,3R,4S)-3,4-dihydro-2,3-dimethyl-4-phenylselenylmethyl-6-trifluoromethylsulfonyloxy-2H-pyran 
• 139301-76-1 (3S,4R,5R)-5-acetoxy-3-acetoxymethyl-4-methylhexanoic acid 
• 139403-50-2 (4R,5R,6R)-5,6-Dimethyl-4-(phenylselanylmethyl)tetrahydro-2H-pyran-2-one 
• 139301-87-4 (3S,4R,5R)-5-acetoxy-3-acetoxymethyl-4-methylhexanal 
• 139301-75-0 (2R,3R,4S)-2-acetoxy-4-(acetoxymethyl)-3-methyl-6-heptene 
• 139301-77-2 (4R)-dihydro-4-<(1R,2S)-2-hydroxy-1-methylpropyl>furan-2(3H)-one 
• 139301-74-9 (3R,4R,5R)-dihydro-4,5-dimethyl-3-(2-propenyl)furan-2(3H)-one 
• 139301-86-3 (2R,3R,4S)-4-hydroxymethyl-3-methyl-6-hepten-2-ol 
• 139301-90-9 C₄₄H₆₉NO₁₀SeSi 

Downstream Products

• 27973-72-4 (+)-pederine 

Relevant academic research and scientific papers

Total synthesis and biological evaluation of pederin, psymberin, and highly potent analogs

The potent cytotoxins pederin and psymberin have been prepared through concise synthetic routes (10 and 14 steps in the longest linear sequences, respectively) that proceed via a late-stage multicomponent approach to construct the N-acyl aminal linkages.

Pederin: The metallated dihydropyran approach. Stereoselective reduction of N-acylimidates via rhodium-catalysed hydroboration

A synthesis of the insect toxin pederin (1) based upon the union of metallated dihydropyran 8 with the oxamate ester derivative 9 is described. Noteworthy features include (a) a new method for the construction of metallated dihydropyrans which tolerates h