139305-96-7

Basic information

• Product Name: (S)-1-(3-Bromophenyl)ethylamine
• Synonyms: (S)-3-BROMO-ALPHA-METHYLBENZYLAMINE;(S)-(-)-3-BROMO A-METHYLBENZYLAMINE;(S)-1-(3-BROMOPHENYL)ETHANAMINE;(S)-1-(3-BROMOPHENYL)ETHYLAMINE;3-Bromo-alpha-methylbenzylamine;(S)-(-)-3-BROMO-ALPHA-METHYLBENZYLAMINE HYDROCHLORIDE;(S)-1-(3-Bromophenyl)ethylamine, ChiPros 99%, ee 98+%;Benzenemethanamine, 3-bromo-α-methyl-, (αS)-
• CAS NO: 139305-96-7
• Molecular Formula: C₈H₁₀BrN
• Molecular Weight: 200.08
• Product Categories: API intermediates
• Mol File: 139305-96-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 96°C/4mm
• Flash Point: 96°C/4mm
• Appearance: /
• Density: 1.33
• Vapor Pressure: 0.024mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 8.73±0.10(Predicted)
• Water Solubility: Immiscible with water.
• Sensitive: Air Sensitive
• BRN: 4798483
• CAS DataBase Reference: (S)-1-(3-Bromophenyl)ethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(3-Bromophenyl)ethylamine(139305-96-7)
• EPA Substance Registry System: (S)-1-(3-Bromophenyl)ethylamine(139305-96-7)

Safety Data

• Hazard Codes: C,N
• Statements: 36/37/38-51/53-34-22
• Safety Statements: 26-36/37/39-61-45
• RIDADR: UN2735
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 139305-96-7(Hazardous Substances Data)

Usage

Uses

(S)-1-(3-Bromophenyl)ethylamine is involved in the Ullmann coupling reaction with N-H containing heteroarenes using copper iodide as a catalyst.

InChI:InChI=1/C8H10BrN/c1-6(10)7-3-2-4-8(9)5-7/h2-6H,10H2,1H3/t6-/m0/s1

Upstream product

• 2142-63-4 1-(3-Bromophenyl)ethanone 
• 109-73-9 N-butylamine 
• 124-20-9 N-(3-aminopropyl)-1,4-diaminobutane 
• 110-60-1 1,4-diaminobutane 
• 24280-05-5 N-[1-(3-bromophenyl)ethylidene]hydroxyl amine 
• 52780-14-0 (R)-1-(3-bromophenyl)ethanol 
• 185527-07-5 N-[1-(3-Bromo-phenyl)-ethyl]-oxalamic acid octyl ester 
• 74877-08-0 1-(3-bromophenyl)ethanamine 
• 108-22-5 Isopropenyl acetate 
• 3938-96-3 ethyl 2-methoxyacetate 
• 539-88-8 4-oxopentanoic acid ethyl ester 
• 95-92-1 oxalic acid diethyl ester 
• 623-50-7 ethyl 2-hydroxyacetate 
• 687-47-8 (S)-Ethyl lactate 

Downstream Products

• 595571-87-2 (S)-1-(3-pyrazol-1-yl-phenyl)ethylamine 
• 477312-85-9 (S)-[1-(3-bromophenyl)ethyl]carbamic acid tert-butyl ester 
• 1213424-35-1 (S)-1-(3-phenoxyphenyl)ethanamine 
• 477312-91-7 [(S)-1-(phenyl 3-boronic acid)-ethyl]-carbamic acid tert-butyl ester 
• 701914-07-0 {1-[3-(3-dimethylamino-pyrrolidin-1-yl)-phenyl]-ethyl}-carbamic acid tert-butyl ester 
• 701914-08-1 {1-[3-(1-amino-ethyl)-phenyl]-pyrrolidin-3-yl}-dimethyl-amine 
• 701913-93-1 (S)-2-phenyl-cyclopropanecarboxylic acid [1-(3-pyridin-3-yl-phenyl)-ethyl]-amide 
• 697804-10-7 (S)-1-(3-pyridin-3-yl-phenyl)-ethylamine 
• 1100768-29-3 N-(4-carbamimidoyl-phenyl)-N'-[1-(4'-methanesulfonylamino-biphenyl-3-yl)-ethyl]-malonamide trifluoroacetate 

Relevant articles and documents

Enantioselective enzymatic acylation of 1-(3′-bromophenyl)ethylamine

An efficient biocatalytic process has been developed for the resolution of 1-(3′-bromophenyl)ethylamine (RS)-1 by way of enantioselective lipase-mediated (R)-selective acylation with ethyl 2-methoxyacetate to afford (S)-amine (S)-1 and (R)-2″-methoxyaceta

Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases

The discovery and characterisation of enzymes with both monoamine and diamine transaminase activity is reported, allowing conversion of a wide range of target ketone substrates with just a small excess of amine donor. The diamine co-substrates (putrescine, cadaverine or spermidine) are bio-derived and the enzyme system results in very little waste, making it a greener strategy for the production of valuable amine fine chemicals and pharmaceuticals.

PROCESS FOR THE PREPARATION OF CHIRAL AMINES FROM PROCHIRAL KETONES

There is provided a method for the preparation of an enantiomerically enriched amine from a prochiral ketone.