1393085-77-2Relevant academic research and scientific papers
Antibacterial, antioxidant and binding studies of some novel diaryl sulphide derivatives
Moosun, Salma,Bhowon, Minu G.,Jhaumeer-Laulloo, Sabina,Joule, John A.
, p. 1383 - 1400,18 (2020/08/31)
A series of novel acyclic and cyclic diaryl sulphides was synthesized from 2,2-dithiobenzoic acid. The various diaryl sulphides were characterized by use of spectral (IR, 1H and 13C NMR, ESI/MS) and elemental analyses. The antimicrobial activities of the compounds were evaluated in terms of their minimum inhibition concentration (MIC) against a panel of clinical isolates bacteria and were found to possess only moderate antimicrobial activities. N,N-Bis(2-hydroxyphenyl)-2,2-thiodibenzamide (13), exhibiting a hydroxy group at the phenyl ring, was the most active antimicrobial agent within the series, with MIC values of 0.05 mg mL-1 and 10 mg mL -1 against Staphylococcus aureus and Bacillus cereus, respectively. The antioxidant efficiency of the diaryl sulphides was determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity with 13 being the most active compound. The interaction of 2,2-thiodibenzanilide, N,N-bis(2- methylphenyl)-2,2-thiodibenzamide, and N,N-bis(2-hydroxyphenyl)-2,2- thiobenzamide with guanine, glutamic acid, and urea were studied quantitatively with binding constants ranging from 1 × 103 M1 to 2.7 × 104 M1.
Three anilides of 2,2′-thiodibenzoic acid
Helliwell, Madeleine,Moosun, Salma,Bhowon, Minu G.,Jhaumeer-Laulloo, Sabina,Joule, John A.
, p. o387-o391 (2012/11/07)
The structures of N,N′-bis-(2-methylphenyl)-2,2′- thiodibenzamide, C28H24N2O2S, (Ia), N,N′-bis-(2-ethyl-phenyl)-2,2′-thiodibenzamide, C30H 28N2O2S, (Ib), and N,N′-bis-
