1393119-47-5

Basic information

• Product Name: 5-(3-(difluoromethoxy)-4-hydroxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one
• Synonyms: 5-(3-(difluoromethoxy)-4-hydroxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one
• CAS NO: 1393119-47-5
• Molecular Weight: 350.325
• Mol File: 1393119-47-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-(3-(difluoromethoxy)-4-hydroxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-(difluoromethoxy)-4-hydroxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one(1393119-47-5)
• EPA Substance Registry System: 5-(3-(difluoromethoxy)-4-hydroxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one(1393119-47-5)

Safety Data

• Hazardous Substances Data: 1393119-47-5(Hazardous Substances Data)

Upstream product

• 53173-70-9 3-(Difluoromethoxy)-4-hydroxybenzaldehyde 
• 139756-02-8 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide 

Relevant articles and documents

InCl3-catalysed synthesis of 2-aryl quinazolin-4(3H)-ones and 5-aryl pyrazolo[4,3-d]pyrimidin-7(6H)-ones and their evaluation as potential anticancer agents

A convenient and practical methodology for the synthesis of 2-aryl quinazolin-4(3H)-ones by the condensation of o-aminobenzamides with aromatic aldehydes under mild conditions using catalytic InCl3 with good yields and high selectivities. This method has been extended for the synthesis of 5-aryl pyrazolo[4,3-d]pyrimidin-7(6H)-ones which have potential applications in medicinal chemistry. Many of these compounds were evaluated for their anti-proliferative properties in vitro against four cancer cell lines and several compounds were found to be active. Further in vitro studies indicated that inhibition of sirtuins could be the possible mechanism of action of these molecules.