1393120-65-4

Basic information

• Product Name: C₂₂H₂₅NO₇S
• Synonyms: C₂₂H₂₅NO₇S
• CAS NO: 1393120-65-4
• Molecular Weight: 447.509
• Mol File: 1393120-65-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₅NO₇S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₅NO₇S(1393120-65-4)
• EPA Substance Registry System: C₂₂H₂₅NO₇S(1393120-65-4)

Safety Data

• Hazardous Substances Data: 1393120-65-4(Hazardous Substances Data)

Upstream product

• 834-67-3 4-((4-bromophenyl)sulfonyl)morpholine 
• 1374986-79-4 C₂₃H₂₇NO₇S 

Downstream Products

• 1374986-53-4 3-((3-methylbut-2-en-1-yl)oxy)-5-(4-(morpholinosulfonyl)phenoxy)-N-(thiazol-2-yl)benzamide 
• 1374986-54-5 N-(5-fluorothiazol-2-yl)-3-((3-methylbut-2-en-1-yl)oxy)-5-(4-(morpholinosulfonyl)phenoxy)benzamide 

Relevant articles and documents

Design, synthesis, and pharmacological evaluation of benzamide derivatives as glucokinase activators

A series of benzamide derivatives were assembled by using the privileged-fragment-merging (PFM) strategy and their SAR studies as glucokinase activators were described. Compounds 5 and 16b were identified having a suitable balance of potency and activation profile. They showed EC50 values of 28.3 and 44.8 nM, and activation folds of 2.4 and 2.2, respectively. However, both compounds displayed a minor reduction in plasma glucose levels on imprinting control region (ICR) mice. Unfavorable pharmacokinetic profiles (PK) were also observed on these two compounds.