1393135-56-2Relevant academic research and scientific papers
Chiral cyclohexane 1,3-diones as inhibitors of mutant SOD1-dependent protein aggregation for the treatment of ALS
Zhang, Yinan,Benmohamed, Radhia,Zhang, Wei,Kim, Jinho,Edgerly, Christina K.,Zhu, Yaoqiu,Morimoto, Richard I.,Ferrante, Robert J.,Kirsch, Donald R.,Silverman, Richard B.
, p. 584 - 587 (2012/09/10)
Cyclohexane 1,3-diones were identified as a class of molecules exhibiting a protective effect against mutant SOD1 induced toxicity in PC-12 cells, but an optimized analogue had little or no effect on life extension in the G93A SOD1 mouse model for amyotro
