139331-72-9Relevant academic research and scientific papers
Benzoxazine and benzothiazine derivatives and their use in pharmaceuticals
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Page column 12, (2010/01/31)
Described are benzoxazine and benzothiazine compounds of the formula I defined herein, methods for their preparation and methods for their use in pharmaceuticals based on their activity as NO-synthases (NOS) inhibitors.
Synthesis and biological activities of new 1,4-benzothiazine derivatives
Kajino,Mizuno,Tawada,Shibouta,Nishikawa,Meguro
, p. 2888 - 2895 (2007/10/02)
New 2H-1,4-benzothiazin-3(4H)-one derivatives possessing (4-phenyl-1-piperazinyl)alkyl moieties at the 2-position were synthesized and tested for calcium antagonistic and calmodulin antagonistic activities. Antihypertensive effects in spontaneously hypertensive rats were also evaluated. In general, these compounds were rather weak calcium channel blockers, although, in contrast, many of them had moderate to potent calmodulin antagonistic activity, and 2-[3-(4-(4-fluorophenyl)-1-piperazinyl]propyl]-2H-1,4-benzothiazin-3(4H )-one derivatives 45, 74 and 75 showed potent antihypertensive effects.
