139342-89-5Relevant academic research and scientific papers
Asymmetric Dipolar Cycloaddition of Nitrile Oxides to the α,β-Unsaturated Esters Bearing an Imidazolidine Chiral Controller at the β-Position
Kanemasa, Shuji,Hayashi, Takashi,Yamamoto, Hidetoshi,Wada, Eiji,Sakura, Tosio
, p. 3274 - 3279 (2007/10/02)
Some α,β-unsaturated esters bearing an imidazolidine chiral controller at the β-position were employed in the asymmetric cycloaddition to nitrile oxides.Regio- and diastereoselectivities were both poor when the chiral controller was a perhydropyrroloimidazol-3-yl auxiliary, while the reaction of the esters bearing a C2-symmetric imidazolidine chiral controller was exclusively regioselective or diastereoselective depending upon the nature of N-substituent.The transition state was briefly discussed.
