1393447-77-2Relevant academic research and scientific papers
Experimental and theoretical study on the reaction of N3-phenyl- (pyridin-2-yl)carbohydrazonamide with itaconic anhydride
Modzelewska-Banachiewicz, Bozena,Paprocka, Renata,Mazur, Liliana,Saczewski, Jaros?aw,Kutkowska, Jolanta,Stepień, Dorota K.,Cyrański, Micha?
, p. 211 - 219 (2012)
Two new 1,2,4-triazole-containing alkenoic acid derivatives were obtained from the reaction of N-phenyl-(pyridin-2-yl)carbohydrazonamide with itaconic anhydride, depending on the reaction conditions. The structures of 2-((4-phenyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)methyl)acrylic acid or (E)-2-methyl-3(4-phenyl-5-(pyridine-2-yl)-4H-1,2,4-triazol-3-yl)acrylic acid were confirmed by means of 1D and 2D NMR spectroscopic data as well as by single-crystal X-ray diffraction analysis. The experiential 1H and 13C chemical shifts were compared with those calculated with B3LYP, EDF1, and EDF2 density functional theories. The theoretical study of the observed terminal-to-internal alkene isomerization was performed with density functional (DFT) B3LYP/6-31+G method using SM8 water and DMF solvation models. Antimicrobial activities of the newly prepared alkenoic acid derivatives were verified experimentally by a broth microdilution method.
Synthesis and anti-inflammatory activity of new 1,2,4-triazole derivatives
Paprocka, Renata,Wiese, Malgorzata,Eljaszewicz, Andrzej,Helmin-Basa, Anna,Gzella, Andrzej,Modzelewska-Banachiewicz, Bozena,Michalkiewicz, Jacek
supporting information, p. 2664 - 2667 (2015/06/08)
The series of new 1,2,4-triazole derivatives with methacrylic acid moiety were synthesized and characterized by NMR and IR spectroscopy as well as X-ray crystallography. The influence of newly synthesized compounds on the inflammation on the level of cyto
