139345-12-3

Upstream product

• 34026-01-2 (2,2,6-trimethylcyclohexyl)methanol 
• 1189-35-1 3,7-dimethylocta-1,6-diene-3-yl acetate 
• 34026-01-2 (+/-)-trans-2,2,6-trimethyl-1-hydroxymethyl-cyclohexane 
• 5949-05-3 (S)-Citronellal 
• 139406-49-8 (+)-(1R,6S)-2,2,6-trimethylcyclohexane-1-methanol 
• 52567-47-2 (+/-)-2.2.6t-trimethyl-cyclohexane-carboxylic acid-(1r)-methyl ester 
• 78842-55-4 2-[1,3]dioxolan-2-yl-1,3,3-trimethyl-cyclohexene 
• 693778-98-2 C-(2,2,6-trimethyl-cyclohexyl)-methylamine 

Downstream Products

• 153061-05-3 (+)-(1'S,6'S,E)-1-(2',2',6'-trimethylcyclohexyl)hex-1-en-3-one 
• 153061-04-2 (+)-(1'S,6'S,E)-4-(2',2',6'-trimethylcyclohexyl)but-3-en-2-one 
• 150850-54-7 (1R,6S)-2,2,6-trimethylcyclohexanecarboxylic acid 
• 1441168-58-6 2-(3-fluorophenyl)-1-((1R,6S)-2,2,6-trimethylcyclohexyl)ethanone 
• 1441168-38-2 1,2-difluoro-4-(((1R,6S)-2,2,6-trimethylcyclohexyl)methoxy)benzene 
• 1441168-36-0 1-chloro-3-(((1R,6S)-2,2,6-trimethylcyclohexyl)methoxy)benzene 
• 1441168-34-8 1-fluoro-3-(((1R,6S)-2,2,6-trimethylcyclohexyl)methoxy)benzene 
• 139406-49-8 (+)-(1R,6S)-2,2,6-trimethylcyclohexane-1-methanol 
• 1441168-06-4 3-fluoro-N-methyl-N-(((1R,6S)-2,2,6-trimethylcyclohexyl)methyl)aniline hydrochloride 
• 1441192-63-7 3-fluoro-N-methyl-N-(((1R,6S)-2,2,6-trimethylcyclohexyl)methyl)aniline 
• 1441168-04-2 3-fluoro-N-(((1R,6S)-2,2,6-trimethylcyclohexyl)methyl)aniline hydrochloride 
• 1441192-60-4 3-fluoro-N-(((1R,6S)-2,2,6-trimethylcyclohexyl)methyl)aniline 
• 1441168-02-0 3-chloro-N-(((1R,6S)-2,2,6-trimethylcyclohexyl)methyl)aniline hydrochloride 
• 1441192-57-9 3-chloro-N-(((1R,6S)-2,2,6-trimethylcyclohexyl)methyl)aniline 

Relevant academic research and scientific papers

OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE

Compounds I are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related t

OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE

Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to

OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE

Compounds and compositions are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.

OPSIN-BINDING LIGANDS, COMPOSITIONS AND METHODS OF USE

Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.

Fast preparation of dihydrocyclocitral from citronellal under solventless microwave irradiation

Dihydrocyclocitral, a useful reagent in organic synthesis, has been synthesized in high yield and with high stereoselectivity from citronellal under microwave irradiation in two steps, involving acetic anhydride under base catalysis, then p-toluenesulfonic acid adsorbed on silica gel under solventless conditions (80% yield, reaction time 22 min).

The Suzuki Reaction in Stereocontrolled Polyene Synthesis: Retinol (Vitamin A), its 9- and/or 13-Demethyl Analogs, and Related 9-Demethyl-dihydroretinoids

A new synthesis of retinol (vitamin A) and 9- and/or 13-demethylretinols, with essentially complete control of regio- and stereochemistry, is described which is based on the thallium-accelerated, palladium-catalyzed cross-coupling reactions of (E)-1-alkenylboronic acids and (E)-1-alkenyl iodides (Suzuki reaction).The procedure has also been extended to the stereocontrolled synthesis of a series of 9-demethyl-dihydroretinoids of potential biological interest.

Preparation of Optically Active Flowery and Woody-Like Odorant Ketones via Corey-Chaykovsky Oxiranylation: Irones and Analogues

α-, β-, and γ-Irones and analogues have been prepared from optically active (+)-1, (+)-6a,b, and (+)-17, via a Corey-Chaykovsky oxiranylation (Me2S, Me2SO4, Me2SO, NaOH) followed by isomerisation (SnCl4 or MgBr2). (+)-Dihydrocyclocitral (19a), obtained from (-)-citronellal, and analogue (+)-19b, were condensed with various ketones to afford (+)-21a-f, and after hydrogenation (+)-22a-f.A mild oxidative degradation of aldehydes (+)-trans- and (-)-cis-8a,b to ketones (-)-16a,b, as well as olfactive evaluations, 13C-NMR assignments, and absolute configurations of the intermediate epoxides, aldehydes, and alcohols are presented.